The combination of ursolic acid and OXA synergistically impeded the colon cancer cell proliferation and caused apoptosis both in vitro and in vivo via inhibition of mitogen-activated protein kinase (MAPK), PI3K/AKT and NF-κB signaling pathways (Shan et al., 2016). Here, AKT1 is linked to malignant colon neoplasm.