METTL1 knockdown reduces m7G modification of tRNA, affects m7G modified tRNA expression in HCC cells, and leads to tRNA m7G modification promoting the translation of target mRNA with high frequency of m7G-related codons (Chen et al., 2021; Chen J. et al., 2022; Luo et al., 2022; Zhang et al., 2024). Here, METTL1 is linked to hepatocellular carcinoma.