The METTL1/WDR4 complex performs m7G modification at position 46 of the tRNA ring (Cartlidge et al., 2005) to enhance mRNA translation by weakening ribosome suspension (Wang et al., 2023a; Zhang M. et al., 2023), thereby regulating self-renewal and differentiation of embryonic stem cells and playing a role in promoting tumor progression. This evidence concerns the gene METTL1 and neoplasm.