METTL1 and hepatocellular carcinoma: In terms of enhancing invasion and migration, METTL1-mediated m7G tRNA modifications selectively modulate the translation of key genes in the epithelial to mesenchymal transition (EMT) process in a codon frequency dependent manner, and targeting the METTL1-m7G-SLUG/SNAIL axis to prevent HCC metastasis after radiofrequency thermal ablation therapy provides a molecular basis (Zhu et al., 2023).