By promoting p53 ubiquitination, CCNB1 increases the phosphorylation levels of PI3K and AKT in HCC and decreases the expression of p53 protein, thus promoting the proliferation of tumor cells (Xia et al., 2021; Li et al., 2022a, Luo et al., 2022). This evidence concerns the gene TP53 and hepatocellular carcinoma.