After radiation therapy, METTL1 promotes DNA double-strand break (DSB) repair, which promotes non-homologous end junctions of DNA by increasing mRNA translation of DNA-dependent protein kinase catalytic subunits (DNA-PKCs) and DNA ligase IV, leading to radiation resistance in HCC (Liao et al., 2023). The gene discussed is PRKDC; the disease is hepatocellular carcinoma.