SLC10A2 and irritable bowel syndrome: Mutations in the human SLC10A2 gene may lead to bile acid malabsorption, enterohepatic circulation disruption, and lower plasma cholesterol (Slijepcevic and van de Graaf, 2017), and ASBT deficiency may lead to inflammatory bowel disease, constipation and alagille syndrome, familial hypertriglyceridemia, congenital chronic diarrhea, irritable bowel syndrome (IBS), NASH (Dawson, 2011).