More importantly, Loeffelholz et al. reported that SLC13A5 gene expression levels were significantly increased and independently correlated with hepatic steatosis in liver samples from NAFLD patients with obesity for the first time (von Loeffelholz et al., 2017), revealing the relationship between NACT and hepatic steatosis in humans. Here, SLC13A5 is linked to obesity due to melanocortin 4 receptor deficiency.