Additionally, three significant susceptibility loci, rs2651899 (PRDM16), rs10166942 (TRPM8), and rs11172113 (LRP1), are significantly associated with migraine and are related to pain and neurotransmitter pathways, supporting the pathophysiological perspective of migraine (Gerring et al., 2018; Chasman et al., 2011).Furthermore, whole-exome sequencing has identified 17 functional variants in 12 genes, including RETNLB and ADH4, that are closely linked to the occurrence of migraine (Khan et al., 2022). This evidence concerns the gene TRPM8 and migraine disorder.