Numerous exosomal enzymes found in exfoliated kidney cells, such as glycogen synthase kinase-3 beta (GSK-3β) which is mostly detected in higher levels in podocytes but also in PTCs with DM and DKD severity, have been shown to display greater prognostic accuracy for DKD progression when compared with albuminuria [4, 28]. This evidence concerns the gene GSK3B and diabetes mellitus.