Teiten et al. observed that curcumin showed anticancer effect by modulating several proteins involved in crucial cellular processes, including protein folding (heat shock protein PPP2R1A), RNA splicing (RBM17 and DDX39), cell death (HMGB1 and NPM1), and androgen receptor signaling (NPM1 and FKBP4/FKBP52) in androgen-dependent (22Rv1) and androgen-independent (PC-3) human prostate cancer cell lines. Here, HMGB1 is linked to prostate cancer.