KEGG pathway enrichment analysis of these DEGs revealed significant enrichment in pathways pivotal for tumor cell interactions with the microenvironment, including extracellular matrix (ECM)-receptor interactions, cytokine-cytokine receptor interactions, cell adhesion molecules, TNF signaling, Ras signaling, and PI3K-Akt signaling pathways (Figure 2C). This evidence concerns the gene TNF and neoplasm.