For example, miR-181a as the newly discovered controller of cardiac remodeling, played a role in the regulation of autophagy, the p53-p21 pathway, PTEN/PI3K/AKT signaling, and the aldosterone-mineralocorticoid receptor (AldoMR) pathway in myocardial hypertrophy (130, 131). Here, AKT1 is linked to cardiac hypertrophy.