investigated the functional role of miR-21-3p in cardiac hypertrophy and demonstrated that its overexpression significantly mitigates TAC (transverse aortic constriction)-induced cardiac hypertrophy and Ang II-induced cardiac hypertrophy by suppressing HDAC8 expression to activate the Akt/Gsk3b pathway (111). The gene discussed is GSK3B; the disease is cardiac hypertrophy.