TP53 and type 2 diabetes mellitus: As a result, we found 144 DEPs up-regulated in T2DM group, were mainly involved in neutrophil degranulation, VEGFA-VEGFR2 signaling pathway, and metabolic bioprocesses (oxidative phosphorylation, TP53 regulates metabolic genes, and gluconeogenesis (P < 0.05); while 164 DEPs down-regulated in T2DM group, were enriched in immune related pathways, including chemokine signaling pathway, and innate immune system (Fig. 2C).