In addition to amyloid- and tau-related pathology, AD in DS is characterized by neuroinflammatory processes due to overexpression of inflammation-associated genes on chromosome 21, among which Coxsackievirus And Adenovirus Receptor (CXADR), A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1), and superoxide dismutase 1 (SOD1). Here, MAPT is linked to Alzheimer disease.