In our study, SNRPB expression was elevated in HCC tissues, and SNRPB knockdown promoted the shift from EZH2-A splice isoform to EZH2-C isoform, decreased histone methyltransferase activity, reduced H3K27 trimethylation, and led to impaired expression of cell cycle-related proteins, thereby inhibiting HCC cell survival via BMP2 signaling pathway. Here, SNRPB is linked to hepatocellular carcinoma.