,21,22 In this study, we identified a splice variant of EZH2, EZH2-C, which has a function opposite to the canonical full-length EZH2 (named here as EZH2-A) based on three line of evidence; (1) Expression analysis of mRNAs showed that the levels of EZH2-A in normal liver tissues were lower than those in NAT of liver cancer patients while the levels of EZH2-C in normal liver tissues were higher than those in NAT of liver cancer patients. This evidence concerns the gene BRD2 and liver cancer.