Numerous researches have identified the prevalent genes associated with IESS as TSC1, TSC2, CDKL5, ARX, KCNQ2, STXBP1, SCN2A, SCN8A, NF1, among others, while common chromosomal abnormalities include Down syndrome (9, 17–19). The gene discussed is KCNQ2; the disease is Down syndrome.