Significant differences were observed in ALT normalization, which was higher in the silymarin group for HBV (23.1% vs. 10.0%, p=0.038), and ALT levels, with lower mean values in the silymarin group for HCV (67.58 ± 22.41 U/L vs. 80.91 ± 23.64 U/L, p=0.014) and NAFLD (42.43 ± 16.90 U/L vs. 67.92 ± 30.47 U/L, p=0.013). This evidence concerns the gene GPT and metabolic dysfunction-associated steatotic liver disease.