LGI1 and familial mesial temporal lobe epilepsy: For example, autosomal dominant lateral temporal lobe epilepsy (ADLTE) is associated with mutations in the LGI1 gene, whereas familial mesial temporal lobe epilepsy (FMTLE) encompasses various subtypes (e.g., hippocampal sclerosis, febrile seizures) but has not yet been conclusively linked to a single gene.