MAPT and early-onset autosomal dominant Alzheimer disease: The present work investigates the solubility, activity, and microcrystal electron diffraction (MicroED) (4, 5) structure of co-crystal formulations of the natural product dihydromyricetin (DHM), a brain-permeable flavonoid with high chemical similarity to a known in vitro tau inhibitor, epigallocatechin gallate (EGCG), which is involved in Alzheimer’s disease (AD) pathology (6).