In addition, ORA for KEGG pathways revealed a statistically significant overrepresentation of these genes belonging to four pathways: TNF signaling pathway (Padj = .003), IL-17 signaling pathway (Padj = .011), rheumatoid arthritis (Padj = .039), and PPAR signaling pathway (Padj = .041). The gene discussed is TNF; the disease is rheumatoid arthritis.