CCN2 and neoplasm: Moreover, there also exist several potential factors that are associated with IFP and tumor vascular architecture, encompassing PIEZO1-mediated regulation of endothelial NOS and calpain 2 [352], a non-canonical Notch downstream effector RAC1 [353], YAP/TAZ-induced expression of cysteine-rich angiogenic inducer 61 (CYR61), connective tissue growth factor (CTGF), and ankyrin repeat domain 1 (ANKRD1) [354], as well as JNK signaling [355].