Furthermore, we hypothesized that CAR-T cell stimulation will sensitize tumor cells to ferroptosis via acyl-CoA synthetase long chain family member 4 (ACSL4) and phosphatidylcholine with diacyl-polyunsaturated fatty acid tails (PC-PUFA2) pathways, providing dual mechanisms of anti-tumor activity. This evidence concerns the gene ACSL4 and neoplasm.