After detecting cell cycle-related key proteins, we found that the expression of cyclin B1 and CDC2 was down-regulated in AdipoR1 knockdown cells (Fig. 1F-G) and there is a positive correlation between AdipoR1 and cyclin B1 in hepatocellular carcinoma (Fig. 1H), suggesting that AdipoR1 may regulate cell cycle through cyclin B1. The gene discussed is CCNB1; the disease is hepatocellular carcinoma.