In previous studies, we have shown that AdipoR1 promotes the radiosensitivity of HCC cells by activating the ferroptosis pathway in HCC cells, but here we found that AdipoR1 can also regulate cell radiosensitivity by mediating another pathway that has not been reported, the cell cycle pathway (Pfeiler et al. 2010; Tsukada et al. 2011; Byeon et al. 2010). This evidence concerns the gene ADIPOR1 and hepatocellular carcinoma.