After detecting cell cycle-related key proteins, we found that the expression of cyclin B1 and CDC2 was down-regulated in AdipoR1 knockdown cells (Fig. 1F-G) and there is a positive correlation between AdipoR1 and cyclin B1 in hepatocellular carcinoma (Fig. 1H), suggesting that AdipoR1 may regulate cell cycle through cyclin B1. This evidence concerns the gene ADIPOR1 and hepatocellular carcinoma.