Interestingly, Mifepristone, a GR antagonist, resolved psychosis and depression symptoms in Cushing’s patients (van der Lely et al, 1991; Chu et al, 2001) but was not effective in MDD patients without Cushing’s syndrome (Table 1), aligning with our results. This evidence concerns the gene NR3C1 and Cushing syndrome due to macronodular adrenal hyperplasia.