LHX8 and Infertility: As ZNF281, LHX8, and SOHLH1 are highly expressed during human folliculogenesis, linked as causal genetic determinants of infertility when mutated, and in the case of, Lhx8 and Sohlh1, found in mouse models to induce oocyte-like formation from stem cells, it is highly likely they play critical roles during in vivo oogenesis (Pangas et al, 2006; Zhang et al, 2018b; Hamazaki et al, 2021).