The negative correlation observed between CSF/plasma and saliva levels of NfL was also consistent with the negative association we observed between salivary NfL and TMS and chorea symptoms in Cohort 1, whereby on the other hand, positive correlations were detected between CSF/plasma levels of NfL and these motoric symptoms, consistent with past studies [23, 28, 29, 50]. The gene discussed is NEFL; the disease is Chorea.