To demonstrate the human relevance of our findings, we conducted a comparative analysis of Tlr7/8 mRNA expression and its correlation with signature genes of various cell types in tumor biopsies of patients who received type I IFN (n = 29) and who did not (n = 14) (The Cancer Genome Atlas (TCGA)–Skin Cutaneous Melanoma project (SKCM)). Here, TLR7 is linked to neoplasm.