We found that the antitumor effect of IMQ was strongly diminished in c-JunΔ/ΔMx1-Cre mice (Fig. 6a), c-JunΔ/ΔCD11c-Cre mice (Fig. 6b) and Ccl2−/− mice (Fig. 6c); however, the lack of c-Jun or Ccl2 did not have a significant impact on the growth of orthotopic B16-F10 melanomas in untreated control mice. This evidence concerns the gene JUN and melanoma.