Considering that peripheral neuropathy and synaptic retraction may be implicated in ZIKV-induced paralysis12, we used multiple gene ontology terms focused on nerve and synaptic functions to identify 8 candidate biphasic DEGs (Sparcl1, Sparc, Ptk2b, Grn, Syp, Ank3, Sptbn1, Epb41l3). This evidence concerns the gene SPARC and peripheral neuropathy.