Among the various immune cells within TME, CD8+T cells are considered central to anti-tumor immunity.9 In early stages of tumorigenesis, naive CD8+T cells undergo antigen and costimulatory signal activation, initiating TCR signal transduction wherein LCK, a Src family tyrosine kinase, serves as a key player in antigen-specific TCR signaling.10,11 Proper activation of CD8+T cells is vital for mounting an effective immune response against the tumor. The gene discussed is CD8A; the disease is neoplasm.