Similarly, Vcp depletion in tumor cells increased tumor cells apoptosis (Supplementary Fig. 3e), reduced apoptosis of CD8+T cells (Fig. 2f and Supplementary Fig. 3f), promoted proliferation of CD8+T cells (Fig. 2g and Supplementary Fig. 3g), as well as cytokines expression (Fig. 2h), which ruled out the impact of VCP on tumor antigen presentation. This evidence concerns the gene CD8A and neoplasm.