To ascertain whether G3P displays similar changes in vivo, we isolated tumor interstitial fluid (TIF) from subcutaneous tumors and spontaneous tumor models, finding reduced G3P levels in Vcp-depleted subcutaneous tumors and elevated levels in Vcp-overexpressing spontaneous tumors (Fig. 3e and Supplementary Fig. 4e). The gene discussed is VCP; the disease is neoplasm.