Considering that SARS-CoV-2 virus uses this receptor as an entry point into host cells, increased degradation of angiotensin-converting enzyme 2 (ACE2) could lead to a prolonged inflammatory cytokine storm, oxidative stress, and activation of hemostasis, all of which are characteristic indicators of severe or critical COVID-19 illness.10,18 Moreover, the disease and the subsequent period of isolation and recovery can induce a sedentary lifestyle and poor dietary habits, contributing to the increased risk of hypertension and high cholesterol. This evidence concerns the gene ACE2 and Hypertension.