AutoDoc Vina was used which determined the binding energies and the highest binding scores obtained by Indolizine, 2-(4-methylphenyl)- in NSCLC at RET gene (PDB ID: 6NEC) while second highest binding energy in PIK3CA (PDB ID: 7L1B), and TCTN3 gene (PDB ID: 7QRX) as compared to RET gene as shown in S4 Table. This evidence concerns the gene PIK3CA and non-small cell lung carcinoma.