BRAF and neoplasm: Significantly worse EFS persisted in patients with rare KIAA1549::BRAF breakpoints relative to those with 16:11 breakpoints in a multivariate model, even when accounting for degree of tumor resection (1.9 vs. 2.9 years, hazard ratio (HR) = 4.6, 95% CI = 1.1–18.5, P = .03, Figure 3F).