Since Smoc2 is expressed by interstitial fibroblasts in the OM (57), and is increased in OM myofibroblasts after IRI-AKI (58), these findings suggest that Fib-1, Fib-3, and Fib/Myofib-4 cells are likely to be localized in the OM and give rise to OM myofibroblasts. This evidence concerns the gene SMOC2 and acute kidney injury.