For example, biallelic LoF mutations in the LIFR gene cause Stüve-Wiedemann syndrome-1 (STWS1; OMIM:601559), a fatal neonatal disorder characterized by skeletal dysplasia, feeding difficulties, respiratory distress, and hyperthermia (Figure 5) (32–35). This evidence concerns the gene LIFR and Stüve-Wiedemann syndrome 1.