IFN-α can also induce effector T cells to increase the levels of IFN-γ and TNF-related apoptosis-inducing ligand (TRAIL) and then kill vSMCs in AS through a TRAIL-DR5-dependent apoptosis mechanism, which may lead to plaque instability and increase the risk of acute coronary syndrome [114]. The gene discussed is TNFSF10; the disease is acute coronary syndrome.