ICAM1 and Disorder of lipid metabolism: However, the thickness of the glycocalyx decreases in the atherosclerotic plaque area, which leads to the exposure of vascular adhesion molecules such as intercellular adhesion molecule-1 (ICAM-1) and vascular adhesion molecule-1 (VCAM-1) expressed by ECs [94], and circulating monocytes are selectively recruited from the blood into the intima and differentiated into macrophages and then transformed into foam cells due to lipid metabolism disorders.