It should be noted that hyponatremia will spontaneously and rapidly improve by removing the cause(s) of non-osmotic AVP secretion (e.g., ECF volume depletion, vomiting, and pain), even if urine ([Na+] + [K+]) is above serum [Na+] in cases of AVP secretion due to non-osmotic stimuli. This evidence concerns the gene AVP and Hyponatremia.