Angiotensin-converting enzyme inhibitors (ACEi), proton pump inhibitors (PPIs), and nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with hyponatremia, although at a low incidence [56]. The pathogenesis of medication-induced hyponatremia can be classified into mechanisms involving the relative amounts of free water and Na+ in the body and the factors that regulate body water and Na+ homeostasis. Here, ACE is linked to Hyponatremia.