In cancer cells, characterized by rapid and unleashed proliferation, enzymes involved in the 1 C metabolism pathway, as the mitochondrial serine hydroxymethyltransferase, SHMT2, and the methylenetetrahydrofolate dehydrogenase MTHFD2, are commonly upregulated to produce the required nucleotides and amino acids [12, 13]. This evidence concerns the gene MTHFD2 and cancer.