SAM/SAH ratio reduction caused by either folate starvation, polymorphism-associated reduction of MTHFR activity, or SAH administration, was indeed shown to suppress H3K27 and H3K9 methyltransferases and target methylation across the whole genome of AML cells, mediating resistance to MYC-targeting therapies [19]. This evidence concerns the gene MTHFR and acute myeloid leukemia.