PSA = prostate-specific antigen; PFS = progression-free survival; HR = hazard ratio; CI = confidence interval; PSMA = prostate-specific membrane antigen; PET = positron emission tomography; TTV = total tumor volume ITLV = intensity-weighted lesion volume; SUVmax = maximum standardized uptake value; SUVmean = mean standardized uptake value; SUVpeak = peak standardized uptake value; AP = alkaline phosphatase; LDH = lactate dehydrogenase; Hb = hemoglobin. The gene discussed is KLK3; the disease is neoplasm.