MAPT and type 2 diabetes mellitus: Furthermore, it was shown that the presence of the islet amyloid polypeptide (IAPP) in T2DM patients can accelerate the aggregation of α-synuclein, tau as well as other prion-like proteins through cross-talk (Horvath and Wittung-Stafshede 2016; Denroche and Verchere 2018; Mucibabic et al. 2020).