DICER1 and sarcoma: Histologically, DICER1-related sarcomas show a morphological spectrum ranging from primitive cells (e.g., small blue round cells, spindle cells) to large pleomorphic (anaplastic) cells, arranged in a cambium layer underneath epithelial surfaces [10], and frequently display the characteristic presence of heterologous differentiation in the form of multiple foci of cartilage and sometimes osteoid [11, 12].