Within this subset of cases, there is a significant increase in the presence of CD8 + tumor-infiltrating lymphocytes (TILs), a higher CD8+/CD4 + ratio, and a greater presence of PD-1 + TILs when compared with microsatellite stable tumors and HGSC.114 The highly immunogenic environment suggests that immunotherapy, specifically immune-checkpoint inhibitors (ICI), might be an option to explore. Here, CD8A is linked to neoplasm.