,18,19 Importantly, studies in SF mice could facilitate the understanding of the role(s) of the Foxp3 gene in transcriptive control of other genes associated with Treg cell development, stability, and function and could lead to therapeutic strategies for the IPEX syndrome, IPEX-like syndromes, and other diseases related to Treg deficiency or dysfunction.4 This evidence concerns the gene FOXP3 and immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome.