TYR and Global developmental delay: Currently, there are eight types ofnon-syndromic OCA that have been reported: OCA1 to OCA8 and the most common formsare TYR-related types and include OCA type 1A (MIM 203100) and OCA type 1B (MIM606952) (Manoli et al., 2010; Grønskov et al., 2013; Kausar et al., 2013; Wei etal., 2013; Morice-Picard et al.,2014; Garrido et al., 2021).Furthermore, syndromic OCA includes systemic phenotypic manifestations such asintellectual disability, global developmental delay, and cataract.