A total of seven circulating proteins were associated with both adiposity (in Step ii of the main analysis plan) and a CRC outcome in UVMR and colocalization analyses (in Step iii), labeled by name in Figs 4 and 6: ACE, CCM2, GREM1, HHIP, LPH, NID2, TM190. This evidence concerns the gene HHIP and colorectal carcinoma.