AKT1 and viral infectious disease: KEGG analyses of DEGs or upregulated genes in HBoV1-infected MA104 cells both revealed that common targets were mainly enriched in the PI3K-Akt signaling pathway, cytokine–receptor interactions, and the MAPK signaling pathway (Fig. 4F and G), which are closely related to the regulation of viral infections, including DNA and RNA viruses and retroviruses (30, 31).