GSDMD and viral infectious disease: Regarding the recruitment of the NLRP3 inflammosome and the activation of the inflammation-promoting pathway known as pyroptosis, involved in the inflammatory response during different viral infections (70, –, 72), the expression of the key elements of this process (Gsdmd, Casp1, and Il1β) differ in relation to the strain pathogenicity (14, 15, 30, 73, –, 75).