CYP1A2 and cystic fibrosis: Ciprofloxacin, an antibiotic mainly metabolized by CYP1A2, showed an increase in hepatic clearance, as reported by Christenson et al. [55], in contrast to this finding, Kennedy et al. reported that CYP1A2 did not show an increase in hepatic clearance this could be due to limitation of the study conducted on children with mild CF symptoms only [56].