Given the critical role that oxidative stress plays in both the pathogenesis of RA and the development of endothelial dysfunction, investigating the relationship between circulating Humanin levels, non-coding RNAs (GAS5, miR-21, miR-103), and endothelial dysfunction (ED) in patients with RA is of great interest [15]. The gene discussed is GAS5; the disease is rheumatoid arthritis.