As recent studies suggest that p53 can both trigger and inhibit ferroptosis, particularly through the p53/p21 pathway [40,41], Tarangelo et al. [40] found that the p53-p21 axis helps cancer cells to manage metabolic stress from cystine deprivation, inhibiting ferroptotic cell death in U2OS, A549, T98G, H1299, ACHN, and CAKI-1 cell lines. The gene discussed is TP53; the disease is cancer.