For that reason, we also excluded all disorders in steroid metabolism, e.g., congenital adrenal hyperplasia (CAH), steroid 21-hydroxylase deficiency (CYP21A2, MIM *613815, #201910), 11-beta-hydroxylase deficiency (CYP11B1, MIM *610613, #202010, #103900), 17-alpha-hydroxylase/17,20-lyase deficiency (CYP17A1, MIM *609300, #202110), cholesterol desmolase (CYP11A1, MIM *118485, #613743), and 3-beta-hydroxysteroid dehydrogenase (HSD3B2, MIM *613890, #201810). Here, CYP11B1 is linked to hyperinsulinemic hypoglycemia, familial, 4.