Moreover, PBMC YTHDF2 mRNA expression in RA patients was negatively correlated with erythrocyte sedimentation rate (ESR), CRP levels, and white blood cell (WBC) levels, which are typical markers of inflammation and with serum levels of RF, indicating that YTHDF2 might play a negative regulatory role in RA progression. The gene discussed is CRP; the disease is rheumatoid arthritis.