Among the most studied EDCs, insecticidedichlorodiphenyl-trichloroethane (p,p′-DTT) and the synthetic non-steroidal estrogen diethylstilbestrol (DES) were both central proof-of-concept substances to the discovery of endocrine disruption and were used in the initial investigation to support RACK1 as a potential target of EDCs and their immunotoxicity [5,149,150,151]. This evidence concerns the gene RACK1 and immune system toxicity.