NPPB and hydrops fetalis: For example, one study proposed the following age-dependent NT-proBNP cut-off scores to rule out HF: 50 pg/mL for those < 50 years, 75 pg/mL for 50–75 years old, and 250 pg/mL for those over 75 years [34], while a general consensus study proposed NT-proBNP ≥ 125 pg/mL for patients under 50 years, ≥250 pg/mL for patients aged 50–75 years, and ≥500 pg/mL for patients over 75 years [21], while for even older patients (85+ years), an NT-proBNP value of 400 pg/mL was particularly useful as an HF screening instrument for those with an LVEF 40% and below [35].