The authors observed that centenarians present statistically significant high levels of irisin (35.3 ± 5.5 ng/mL) when compared to both healthy young controls (20.7 ± 6.3 ng/mL) and patients who had experienced a myocardial infarction (15.1 ± 5.4 ng/mL). This evidence concerns the gene FNDC5 and myocardial infarction.